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This systematic review aims to systematically evaluate the efficacy and safety of Chinese patent medicines with resolving hard lump function for the treatment of cyclomastopathy. We searched CNKI, WanFang, SinoMed, PubMed, EMbase, and The Cochrane Library from the inception to January 3 2018, to collect the randomized controlled trials（RCTs）on Chinese patent medicines with resolving hard lump function in treating cyclomastopathy. Two reviewers independently screened literature, extracted data and assessed the methodological quality of included studies. Then, statistical analysis was performed by using Stata 12.0 and WinBUGS 1.4.3 software. A total of 52 RCTs involving 9 605 patients were finally included. The inventions included 11 commercial Chinese patent medicines with functions of resolving hard lump, such as Rupi Sanjie Capsules, Xiaoru Sanjie Capsules, Ruhe Sanjie Pills, and Hongjin Xiaojie Capsules. The result of direct Meta-analysis showed that: as compared with the simple western medicine group, the Chinese patent medicines such as Hongjin Xiaojie Capsules, Ruhe Sanjie Pills, Rupi Sanjie Capsules, Xiaoru Sanjie Capsules and Xiakucao Oral Liquid could significantly improve the clinical efficacy. In addition, the incidence of adverse reactions of Chinese patent medicines with resolving hard lump function was lower than that in Western medicine group in gastrointestinal reactions, menstrual disorders, leucorrhea abnormalities, liver dysfunction and estrogen-like effect. The network Meta-analysis showed that: Xiaoru Sanjie Capsules, Ruhe Sanjie Pills, Yanlu Rukang Capsules, Quyu Sanjie Capsules, and Hongjin Xiaojie Capsules were the top five in terms of treatment effect. Chinese patent medicines with resolving hard lump function had better clinical efficacy. Due to the low quality of included studies， more high quality RCTs are needed to verify the above conclusion.
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Objective To investigate the recognition of cyclomastopathy in female college students in Guangzhou.Method 300 female college students(90 medical students and 210 non-medical students)from 10 colleges in Guangzhou were involved in the survey using the self-designed questionnaire.Results Medical students had significantly higher recognition about cyclomastopathy than non-medical students(all P<0.05).The college students lacked of awareness of self breast care.Only 15.56%of the medical students and 11.43% of the non-medical students regularly took breast self-care.Conclusion To improve the social,school and students pay more attention to the breast diseases,strengthen the female university students about breast health education,has improtant significance for improving college students' knowledge of disease of mammary gland hyperplasia.
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Objective To research the mechanism of treating cyclomastopathy with Runingshuang by measuring the blood rheology and mammary microcirculation. Methods 70 female Wistar rats of SPF were randomly divided into seven groups:the blank control group, the pathologic model group, the comparative group of tamoxifen ointment, the comparative group of Sanjierupi Glue, three remedial groups with large, middle and small dosage of Runingshuang. Pathologic model of mammary hyperplasia was made by injecting estrogen and progesterone. Except the former two groups, each group was treated with different drugs. The blood rheology and mammary microcirculation were measured after 30 days. Results Compared with the blank control group, blood viscosity, plasma viscosity, packed cell volume and the fibrinogen of the pathologic model group increased evidently (P
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Objective: To explore the clinical efficacy of Xihuang Pills in treating cyclomastopathy. Methods: Based on inclusion criteria and exclusion criteria, 56 patients with cyclomastopathy were selected, 30 ones in treatment group and take the Xihuang Pills, the other 26 ones were in control group and took Rupixiao Tablets for 3 courses of treatment. Results: The totaleffective rate was 83.33% in the treatment group and that in the control group was 69.22%. The difference between the two groups was statistically significant (P
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TCM has shown prominent effect on treating breast hyperplasia,especially pair herbs has done.This article enumerates several common used herb pairs for treatment of breast hyperplasia from the aspects of soothing the liver and regulating qi,regulating blood and removing blood stasis,resolving phlegm,warming yang and tonification.And analyze the compatible characteristics of common used herb pairs in clinic.
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Objective To evaluate the clinical safety and therapeutic efficacy of Rupiling Granules in treating cyclomastopathy (classified into deficiency of liver and kidney,disharmony of thoroughfare and Ren channels or complicated with syndrome of qi stagnation,blood stasis,or phlegm blended with blood stasis). Methods A randomized,double-blinded,positive drug controlled parallel polycentric trial was carried out. Results Rupiling Granules showed good therapeutic effect on reducing lump in breast,relieving pain of breast,improving TCM symptoms scoring. Conclusion Rupiling Granules is safe and effective for the treatment of cyclomastopathy (deficiency of liver and kidney ,disharmony of thoroughfare and Ren channels or complicated with syndrome of qi stagnation,blood stasis,or phlegm blended with blood stasis)